Product questions
Tune in here for answers to your inquisitive questions!
What is DAKE, and why is it important?
Vitamin DAKE is a thoughtfully formulated blend of the four essential fat-soluble vitamins (D, A, K, and E) designed to work together in balance, just as they do in the body. Many supplements provide these vitamins individually, but research shows th
What is Minerals 101, and why is it important?
Minerals 101 is a comprehensive, broad spectrum mineral formula designed with highly bioavailable forms to help your body efficiently absorb and utilize essential minerals. It’s formulated to support daily energy, metabolic function, and overall well
What is Magnesium 101, and why is it important?
Magnesium 101 is formulated with a highly absorbable form of magnesium called magnesium bisglycinate, which is chelated to glycine. Glycine not only supports relaxation and sleep but also enters metabolic pathways that help produce energy, such as th
What is Motivation 101, and why is it important?
Motivation 101 is a carefully formulated supplement designed to support healthy dopamine levels, mood, focus, and overall mental performance. Dopamine is a key neurotransmitter involved in sleep, memory, movement, attention, and motivation, as well a
What is Organs 101, and why is it important?
Organs 101 is a unique supplement made from 100% grass fed, freeze dried bovine organs sourced from New Zealand. Designed as a food-based source of vitamins and minerals, it provides targeted nutritional support for your body’s key organs. Key Benefi
What is Brain 101, and why is it important?
Brain 101 is a nootropic supplement designed to support brain health, focus, and cognitive performance. It’s formulated to promote cellular energy, mitochondrial support, antioxidant protection, and overall mental clarity. Key Benefits:. Supports mit
What’s the best time to take DAKE & Minerals?
The ideal timing can vary depending on the specific product and your individual needs. For best results, we recommend following the usage directions listed on each product’s packaging. For best results, we recommend taking DAKE and Minerals 101 toget
Does Motivation 101 contain caffeine?
Motivation 101 is formulated using decaffeinated green tea extract. While this means it is not completely caffeine free, the amount is very minimal. 100 mg of green tea extract typically provides about 1 mg of caffeine or less. That said, if you’re p
Does Brain 101 contain caffeine?
Yes, Brain 101 contains a small amount of naturally occurring caffeine from the coffee fruit concentrate. Each serving (2 capsules) has 7 mg of caffeine. Roughly the same as a few sips of green tea. This caffeine level is considered very gentle, espe
Can I take multiple supplements together?
Your health and safety come first. While many supplements can be safely taken together, we recommend consulting a qualified healthcare professional before starting any new supplement or combining products. Everyone’s body is unique, and a healthcare
How should I store my supplements?
All Suppgrade Labs supplements are designed to maintain their quality and potency at room temperature. Simply store them in a cool, dry place away from direct sunlight, and there’s no need for refrigeration. Following these simple steps ensures your
How does Suppgrade Labs ensure product quality and safety?
At Suppgrade Labs, we take product quality and safety seriously. Every step of our supply chain is carefully monitored to ensure traceability, transparency, and consistency:. Raw Material Verification: We confirm the source, handling, and quality of
Are Suppgrade Labs products safe for children?
Suppgrade Labs products and recommended dosages are formulated specifically for adults, based on the needs of an average 150 pound adult. Because children have different nutritional requirements and developing bodies, our products are not intended fo
Want to learn more from Dave Asprey?
Even if Dave isn’t personally answering questions about supplementation, there are plenty of ways to access his insights and expertise:. DaveAsprey.com: Visit his official website for links to all of his resources and brands, and sign up for the Insi
I've heard Vitamin A can be hard on the liver. Should I be concerned?
This is a fair question and worth addressing directly. Vitamin A toxicity — called hypervitaminosis A — is a real condition, but it's associated with chronic, significantly excessive intake, typically from megadose supplementation (think 10,000–25,00
Does Vitamin A need to be taken with food or fat to absorb properly?
Yes — and this is one of the reasons the formula is designed the way it is. Retinyl palmitate is a fat-soluble compound, meaning it requires dietary fat for proper absorption. DAKE includes Medium Chain Triglycerides (MCT) in the formulation specific
How does Vitamin A interact with the other ingredients in DAKE?
The synergy here is intentional and one of the core design principles of the formula. Vitamins A, D, and K are all fat-soluble and share overlapping metabolic pathways. Vitamin D supports immune function and calcium regulation — but requires adequate
Why does DAKE contain 1,515 mcg of Vitamin A? Is that safe?
The tolerable upper intake level (UL) for preformed Vitamin A in adults is 3,000 mcg RAE per day, established by the National Institutes of Health. DAKE delivers 1,515 mcg — right at about half that ceiling — which gives meaningful therapeutic dosing
With so many supplements out there, why does DAKE even include Vitamin A?
Vitamin A doesn't get the cultural moment that Vitamin D or magnesium gets right now — but it's quietly one of the most commonly suboptimal fat-soluble nutrients in modern diets, and its absence creates a real ceiling on what the other fat-soluble vi
Why does DAKE use Vitamin D3 instead of D2?
There are two forms of supplemental Vitamin D — D2 (ergocalciferol, derived from plants) and D3 (cholecalciferol, derived from animal sources or lichen). D3 is the form your body naturally produces when skin is exposed to UVB sunlight, and research c
Why does DAKE contain 5,000 IU of Vitamin D? Is that safe?
The official RDA for Vitamin D sits at 600–800 IU, which reflects the minimum needed to prevent deficiency-related disease — not an optimal level for a health-conscious adult. The tolerable upper intake level set by the NIH is 4,000 IU, but that figu
Can I just get enough Vitamin D from sun exposure instead of supplementation?
Possibly — but sun exposure is a far less reliable Vitamin D source than most people assume. UVB rays, which trigger Vitamin D synthesis in the skin, are only present at sufficient angles for synthesis during certain hours of the day and certain time
Why does Vitamin D need Vitamin K2 to work properly?
This is one of the most important reasons DAKE is formulated as a stack rather than isolated ingredients. Vitamin D significantly increases calcium absorption from the gut — which is exactly what you want for bone density and cellular function. But c
Should I take DAKE with food for better Vitamin D absorption?
Yes — Vitamin D is fat-soluble, and like all fat-soluble nutrients, it absorbs most efficiently in the presence of dietary fat. DAKE includes Medium Chain Triglycerides (MCT) in the formulation as a built-in absorption vehicle for all the fat-soluble
Why does DAKE use K1 and K2 as MK-4 specifically?
Vitamin K exists in several forms, and the differences between them are meaningful — not just marketing. DAKE uses two forms intentionally: K1 (phytonadione) and K2 as MK-4 (menaquinone-4). K1 is the form found in leafy greens and is the primary driv
I've seen other supplements use MK-7 as their K2 source. Why MK-4 in DAKE?
MK-7 is popular in the supplement industry primarily because it has a long half-life in circulation — it stays in the bloodstream for days, which allows for lower doses on a label. That sounds like an advantage, but the research picture is more nuanc
How do K1 and MK-4 work with the Vitamin A, D, and tocotrienols in DAKE?
This is where the formula design really earns its keep. The fat-soluble vitamins in DAKE aren't just coexisting in a capsule — they're working through interconnected pathways that make each one more effective. Vitamin D drives calcium absorption from
Can't I get enough Vitamin K from my diet?
K1 is present in meaningful amounts in leafy greens — spinach, kale, broccoli — so people who eat those regularly may have reasonable K1 status. K2, however, is a different story. Dietary MK-4 comes primarily from grass-fed animal products: butter, e
Why does DAKE use tocotrienols instead of standard Vitamin E (alpha-tocopherol)?
This is one of the most common misconceptions in the supplement world. Vitamin E is actually a family of eight related compounds — four tocopherols and four tocotrienols — and the differences between them are biologically significant, not just techni
What makes tocotrienols different from the tocopherols found in most Vitamin E supplements?
Structurally, tocotrienols have an unsaturated side chain that allows them to move through cell membranes more rapidly and distribute into tissues — particularly brain and liver — more efficiently than tocopherols. This structural difference translat
What is DeltaGold®, and why is it included in DAKE?
DeltaGold® is a tocotrienol extract standardized to deliver a high concentration of delta and gamma tocotrienols — the two forms with the strongest research backing for cardiovascular and metabolic benefits. It's derived from annatto, which is notabl
Why is there no daily value listed for the tocotrienols in DAKE?
The established daily value for Vitamin E is based entirely on alpha-tocopherol, which is the form the original reference intakes were built around. Tocotrienols are a distinct class of compounds with their own research base, and no official daily va
How do the tocotrienols interact with the other ingredients in DAKE?
The tocotrienols in DAKE function as both active ingredients and stack protectors. On the active side, they contribute antioxidant and anti-inflammatory support that complements the bone, cardiovascular, and immune work being done by Vitamins A, D, a
Can I get enough tocotrienols from food?
Tocotrienols are found in palm oil, rice bran, wheat germ, and certain plant oils — but in relatively modest amounts, and dietary intake is highly dependent on food patterns that most people don't follow consistently. Annatto, the source used for Del
Can I take DAKE if I’m on blood-thinning medication like warfarin?
If you are currently taking warfarin (Coumadin) or any other anticoagulant medication, do not start DAKE without first consulting your prescribing physician. This is not general caution language — it is a hard stop. Vitamin K plays a direct role in t
Can I take DAKE during pregnancy or while breastfeeding?
If you are pregnant, trying to conceive, or breastfeeding, consult your OB or midwife before starting DAKE.
Can I take DAKE if I have a liver condition?
If you have a diagnosed liver condition — including fatty liver disease, hepatitis, or cirrhosis — consult your physician before starting DAKE.
Can I take DAKE if I have a condition affecting calcium metabolism?
If you have been diagnosed with hypercalcemia, hyperparathyroidism, sarcoidosis, or any other condition that affects calcium metabolism or regulation, consult your physician before starting DAKE.
Can I take DAKE if I have kidney disease?
If you have diagnosed kidney disease or significantly impaired kidney function, consult your physician before starting DAKE.
Can I take DAKE if I’m taking a statin medication?
If you are currently taking a statin, DAKE is worth discussing with your prescribing physician.
Are the benefits of DAKE different for men and women?
The foundational benefits of DAKE apply to both men and women equally — the fat-soluble vitamin stack addresses biology that isn't gender-specific. Bone density support, cardiovascular protection, immune function, calcium regulation, and cellular ene